Tab 1. Unakrsna reaktivnost glavnih metabolita Cyclosporina

Tabela  1. Unakrsna reaktivnost  glavnih metabolita Cyclosporina 

Metabolit

Bioaktivnost
(%)

Koncentracija srodnika do roditelja (%)

Seimens
ACMIA

Seimens
ADVIA

Microgenics
CEDIA

Roche
EMIT

Syva
EMIT

Abbott
MEIA

AM1 (M17)
1-β-hydroxyl

10–20

80–150

1.8% @
1000 ng/mL

<5% @
1000 ng/mL

4.4% @
1000 ng/mL

<AS @
500 ng/mL

<0.3% @
500 ng/mL -5.9% @
1000 ng/mL

-0.7–1.7% @
1000 ng/mL

AM 9 (M1)
9-γ-hydroxyl

5–10

50–75

2.1% @
1000 ng/mL

15% @
1000 ng/mL

20.0% @
1000 ng/mL

13% @
667 ng/mL

7.3% @
670 ng/mL 5.5% @
1000 ngmL

-3.8–1.9% @
1000 ng/mL

AM 4N (M21)
4-N-demethyl

3–5

5–25

6.0% @
1000 ng/mL

<5% @
1000 ng/mL

16.0% @
1000 ng/mL

5.1% @
500 ng/mL

<0.3% @
500 ng/mL 0.9% @
1000 ng/mL

-2.3–3.1% @
1000 ng/mL

Skraćenice : ACMIA, affinity column-mediated immunoassay; CEDIA, cloned-enzyme donor immunoassay; EMIT, enzyme-multiplied immunoassay; and MEIA, microparticle enzyme immunoassay.

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